RESEARCH INTERESTS

• Protein targeting and transport across cell membrane
• Protein folding and misfolding or amyloid formation
• Membrane protein biogenesis
• Therapeutic treatment of Alzheimer's and Parkinson's disease
• Protein structural and functional studies by NMR and fluorescence spectroscopy

PUBLICATIONS

1. Christopher Sun, Leah Slade, Prisca Mbonu, Hunter Ordner, Connor Mitchell, Matthew Mitchell and Fu-Cheng Liang, (2024) The FEBS Journal, 291, 158-176, Membrane Protein Chaperone and Sodium Chloride Modulate the Kinetics and Morphology of Amyloid Beta Aggregation. [Journal link]
2. Alex Siegel, Camille Z. McAvoy, Vinh Lam, Fu-Cheng Liang, Gerard Kroon, Emily Miaou, Patrick Griffin, Peter E. Wright, Shu-ou Shan (2020) Journal of Molecular Biology, 432, 166708, A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone. [Journal link]
3. Peng Wang, Fu-Cheng Liang, Daniel Wittmann, Alex Siegel, Shu-ou Shan, Bernhard Grimm (2018) Proceedings of the National Academy of Sciences of the United States of America, 115(15), E3588-E3596, Chloroplast SRP43 Acts as a Chaperone for Glutamyl-tRNA Reductase, the Rate-limiting Enzyme in Tetrapyrrole Biosynthesis. [Journal link]
4. Fu-Cheng Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou Shan (2016) Proceedings of the National Academy of Sciences of the United States of America, 113(12), E1615-E1624, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release. [Journal link]
5. Peera Jaru-Ampornpan, Fu-Cheng Liang, Alex Nisthal, Thang X. Nguyen, Steven Mayo, and Shu-ou Shan (2013) The Journal of Biological Chemistry, 288, 13431-13445, Mechanism of an ATP-independent Protein Disaggregase: II. Distinct Molecular Interactions Drive Multiple Steps during Aggregate Disassembly. [Journal link]
6. Fu-Cheng Liang, Umesh K. Bageshwar and Siegfried M. Musser (2012) The Journal of Biological Chemistry, 287, 12703-12714, Position-dependent Effects of Polylysine on Sec Protein Transport. [Journal link]
7. Fu-Cheng Liang, Umesh K. Bageshwar and Siegfried M. Musser (2009) Molecular Biology of the Cell, 20, 4256-4266, Bacterial Sec Protein Transport is Rate-Limited by Precursor Length: A Single Turnover Study. [Journal link]
8. Umesh K. Bageshwar, Neal Whitaker, Fu-Cheng Liang and Siegfried M. Musser (2009) Molecular Microbiology, 74(1), 209-226, Interconvertibility of Lipid- and Translocon- Bound Forms of the Bacterial Tat Precursor pre-Sufl. [Journal link]
9. Marianne M. Lee, Clara E. Isaza, James D. White, Rita P.-Y. Chen, George F.-C. Liang, Hannah T.-F. He, Sunney I. Chan, Michael K. Chan (2009) Proteins: Structure, Function, and Bioinformatics, 77(3), 647-657, Insight into the Substrate Length Restriction of M32 Carboxypeptidases: Characterization of Two Distinct Subfamilies. [Journal link]
10. Rita P.-Y. Chen^, Fu-Cheng Liang, Chung-Tien Lee, Rosa Zerella and Sunney I. Chan (2008) Journal of the Chinese Chemical Society 55(4), 772-781, Contributions of a Surface Hydrophobic Cluster to the Folding and Structural Stability of Ubiquitin. [Journal link]
11. Clara E. Isaza, Xuejun Zhong, Lucia E. Rosas, James D. White, Rita P.-Y. Chen, George F.-C. Liang, Sunney I. Chan, Abhay R. Satoskar and Michael K. Chan (2008) Biochem Biophys Res Commun. 373(1), 25-29, A Proposed role for Leishmania major Carboxypeptidase in Peptide Catabolism. [Journal link]
12. Fu-Cheng Liang, Rita P.-Y. Chen, Chun-Cheng Lin, Kuo-Ting Huang and Sunney I. Chan (2006) Biochem Biophys Res Commun. 342(2), 482-488, Tuning the Conformation Properties of a Peptide by Glycosylation and Phosphorylation. [Journal link]

PRESENTATIONS and CONFERENCES

1. George Liang (2024) Oral Presentation, UGROW workshop at Midwestern State University, Principle and Hands-on Operations of Fluorescence Spectroscopy
2. Andrea Granados Millan and Fu-Cheng Liang (2024) Oral Presentation, 19th Annual UGROW Symposium at Midwestern State University, Exploring the Impact of Salt on Protein Aggregation Kinetics in Familial Alzheimer's Disease Mutations
3. Sydney Macdonald, Zaniya Medlin and Dr. Fu-Cheng Liang (2024) Poster presentation, MSU 22nd Undergraduate Research and Creative Activity Forum, Deciphering the Binding Profiles of Lecanemab, Aducanumab, and Gantenerumab to Various Amyloid-Beta Forms: Insights into Efficacy and Side Effects in Alzheimer's disease Clinical Trials
4. Crae Jackson and Dr. Fu-Cheng Liang (2024) Poster presentation, MSU 22nd Undergraduate Research and Creative Activity Forum, Unraveling the Bi-directional Relationship between Periodontitis and Diabetes: Strategies for Effective Treatment (Literature Review)
5. Kara Rodgers and Fu-Cheng Liang (2024) Poster presentation, MSU 22nd Undergraduate Research and Creative Activity Forum, Membrane Protein Chaperone Modulates the Kinetics and Morphology of Tau Aggregation: A Potential Treatment for Alzheimer's disease
6. Andrew Vann and Fu-Cheng Liang (2024) Oral presentation, MSU 22nd Undergraduate Research and Creative Activity Forum, Leveraging membrane protein chaperones to mitigate familial mutant amyloid beta aggregation: Prospective therapeutic approach for early-onset Alzheimer's disease
7. Kara Rodgers and Fu-Cheng Liang (2024) Poster presentation, 8th Annual Symposium on Brain Health at Texas Tech HSC, Membrane Protein Chaperone Modulates the Kinetics and Morphology of Tau Aggregation: A Potential Treatment for Alzheimer's disease
8. Andrew Vann and Fu-Cheng Liang (2024) Poster presentation, 8th Annual Symposium on Brain Health at Texas Tech HSC, Leveraging membrane protein chaperones to mitigate familial mutant amyloid beta aggregation: Prospective therapeutic approach for early-onset Alzheimer's disease   
9. Isabella Makelaar and Fu-Cheng Liang (2024) Poster presentation, 8th Annual Symposium on Brain Health at Texas Tech HSC, Utilizing membrane protein chaperone to prevent and disrupt alpha synuclein protein aggregation in Parkinson's disease (Best poster presentation award)
10. Connor Mitchell, and Fu-Cheng Liang (2024) Poster Presentation, Great Plains Honors Conference, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation (Best poster presentation award)
11. Kara Rodgers and Fu-Cheng Liang (2024) Poster presentation, American Chemical Society (ACS) National Meeting in New Orleans, Membrane Protein Chaperone Modulates the Kinetics and Morphology of Tau Aggregation: A Potential Treatment for Alzheimer's disease
12. Andrew Vann and Fu-Cheng Liang (2024) Poster presentation, American Chemical Society (ACS) National Meeting in New Orleans, Leveraging membrane protein chaperones to mitigate familial mutant amyloid beta aggregation: Prospective therapeutic approach for early-onset Alzheimer's disease
13. Abigail Matthew and Dr. Fu-Cheng Liang (2023) Oral presentation, MSU 21st Undergraduate Research and Creative Activity Forum, Using Membrane Protein Chaperone to Prevent and Disrupt Familial Mutant of Alpha Synuclein Protein Aggregation in Parkinson's disease
14. Abigail Guinan and Dr. Fu-Cheng Liang (2023) Poster presentation, MSU 21st Undergraduate Research and Creative Activity Forum, Using Membrane Protein Chaperone to Disrupt the Alpha-Synuclein Protein Aggregation: A Potential Treatment for Parkinson's disease
15. Kara Rodgers and Fu-Cheng Liang (2023) Poster presentation, American Chemical Society (ACS) Southwest Regional Meeting (SWRM), Membrane Protein Chaperone Modulates the Kinetics and Morphology of Tau Aggregation: A Potential Treatment for Alzheimer's disease.
16. Andrew Vann and Fu-Cheng Liang (2023) Poster presentation, American Chemical Society (ACS) Southwest Regional Meeting (SWRM), Leveraging membrane protein chaperones to mitigate familial mutant amyloid beta aggregation: Prospective therapeutic approach for early-onset Alzheimer's disease.
17. Isabella Makelaar and Fu-Cheng Liang (2023) Poster presentation, American Chemical Society (ACS) Southwest Regional Meeting (SWRM), Utilizing membrane protein chaperone to prevent and disrupt alpha synuclein protein aggregation in Parkinson's disease.
18. George Liang (2023) Oral Presentation, UGROW workshop at Midwestern State University, Principle and Hands-on Operations of Fluorescence Spectroscopy
19. Abigail Matthew and Fu-Cheng Liang (2023) Oral Presentation, 18th Annual UGROW Symposium at Midwestern State University, Membrane Protein Chaperone Prevents and Disrupts Alpha-Synuclein Protein Aggregation: A Potential Treatment For Parkinson's disease
20. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, and Fu-Cheng Liang (2023) Poster Presentation, 67^th Biophysical Society Annual Meeting in San Diego, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
21. Kara Rodgers and Fu-Cheng Liang (2023) Poster presentation, MSU 20^th Undergraduate Research & Creative Activity forum, Membrane Protein Chaperone Modulates the Kinetics and Morphology of Tau Aggregation: A Potential Treatment for Alzheimer's disease
22. Abigail Guinan and Fu-Cheng Liang (2023) Poster presentation, MSU 20^th Undergraduate Research & Creative Activity forum, Using Membrane Protein Chaperone to Prevent Familial Mutant of Alpha-Synuclein Protein Aggregation in Parkinson Disease
23. Abigail Matthew and Fu-Cheng Liang (2023) Poster presentation, MSU 20^th Undergraduate Research & Creative Activity forum, Using Membrane Protein Chaperone to Prevent Familial Mutant of Alpha-Synuclein Protein Aggregation in Parkinson's Disease
24. Abigail Matthew, Abigail Guinan and Fu-Cheng Liang (2022) Poster presentation, MSU 19^th Undergraduate Research & Creative Activity forum, Using Membrane Protein Chaperone to Prevent Familial Mutant of Alpha-Synuclein Protein Aggregation in Parkinson Disease
25. Connor Mitchell, and Fu-Cheng Liang (2022) Poster Presentation, MSU 19^th Undergraduate Research & Creative Activity forum, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
26. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, and Fu-Cheng Liang (2022) Poster Presentation, MSU celebration of scholarship, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
27. Viviana James, Leslie Cook, Isabella Makelaar, and Fu-Cheng Liang (2022) Poster presentation, MSU celebration of scholarship, Biophysical and Biochemical Characterization of a Familial Mutant of Alpha-Synuclein Protein in Parkinson Disease
28. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, George Liang (2022), Poster Presentation, 15th Annual Honors Program Symposium, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
29. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, and Fu-Cheng Liang (2022) Poster Presentation, Great Plains Honors Conference, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
30. Christopher Sun and Fu-Cheng Liang (2021) Poster Presentation, Midwest Regional Undergraduate Research, Scholarly and Creative Activity Conference, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
31. Christopher Sun and Fu-Cheng Liang (2021) Poster Presentation, National Conference on Undergraduate Research at home, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
32. Christopher Sun and Fu-Cheng Liang (2021) Poster Presentation, Virtual UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
33. Leah Slade and Fu-Cheng Liang (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Concentration of Sodium Chloride Determines the Aggregation Kinetics and Morphology of Amyloid Beta
34. Christopher Sun and Fu-Cheng Liang (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
35. Dianna Daniel, Blanca Turner, and George Liang (2020) Oral Presentation, UGROW Symposium at Midwestern State University, Utilizing Membrane Protein Chaperone to Prevent Amyloid Plaques and Neurofibrillary Tangle Formation in Alzheimer's Disease
36. George Liang (2020) Oral Presentation, UGROW workshop at Midwestern State University, Principles of Fluorescence Spectroscopy and Protein Purification
37. Shermali Ratnasinghe and George Liang (2020) Poster Presentation, Abilene Christian University virtual undergraduate research festival, Identification of Membrane Protein Chaperone as Therapeutics to Prevent Protein Aggregation of Alzheimer's disease
38. Dianna Daniel, Ryan Smith and George Liang (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Utilize Membrane Protein Chaperone as a Treatment to Ameliorate Tau Protein Aggregation
39. Dirgha Vora, Porscha Weaver, George Liang and Jon Scales (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Using Membrane Protein Chaperone to Rescue the Phenotype in a Fly model of Parkinson's disease
40. Prisca Mbonu, Christopher Sun and Fu-Cheng Liang (2020) Oral Presentation, National Conference on Undergraduate Research in Bozeman, Montana (cancelled due to COVID19), Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
41. Matthew Mitchell and Fu-Cheng Liang (2020) Poster Presentation, American Chemical Society National meeting in Philadelphia, PA (cancelled due to COVID19), Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
42. Kameron Shrum and Fu-Cheng Liang (2020) Poster Presentation, American Chemical Society National meeting in Philadelphia (cancelled due to COVID19), LTD Does Not Function as Membrane Protein Chaperone During Protein Targeting in Chloroplast
43. George Fu-Cheng Liang, (2020) Invited Oral Presentation, Biophysics and Quantitative Biology conference and workshop at Midwestern State University entitle, Apply membrane protein chaperone as therapeutics to prevent Alzheimer's disease
44. Shermali Ratnasinghe and George Liang (2019) Poster Presentation, UGRCAF at Midwestern State University, Utilize Membrane Protein Chaperone to Suppress the Amyloid Beta Aggregation
45. Dianna Daniel and George Liang (2019) Poster Presentation, UGRCAF at Midwestern State University, Utilize Membrane Protein Chaperone as a Treatment to Ameliorate Tau Protein Aggregation
46. Fu-Cheng George Liang (2019) Oral Presentation, EURECA workshop at Midwestern State University, Directed Evolution to Improve Protein Folding in vivo
47. Prisca Mbonu and George Liang (2019) Oral Presentation, UGRCAF at Midwestern State University, Directed Evolution of Membrane Protein Chaperone to Ameliorate Protein Aggregation-associated Disease
48. Dolly Mombeyarara, Cheslin Maloney and George Liang (2019) Oral Presentation, UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Parkinson's Disease
49. Prisca Mbonu, Christopher Sun and Fu-Cheng Liang (2019) Oral Presentation, UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
50. Dolly Mombeyarara, Cheslin Maloney and George Liang (2019) Oral Presentation, UGROW Symposium at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Parkinson's Disease
51. Prisca Mbonu, Christopher Sun and Fu-Cheng Liang (2019) Oral Presentation, UGROW Symposium at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
52. Fu-Cheng George Liang (2019) Oral Presentation, UGROW workshop at Midwestern State University, Principle and Hands-on Operations of Fluorescence Spectroscopy
53. Kameron Shrum, Tyler Jones and F.C. Liang (2019) Poster Presentation, Texas Undergraduate Research Day at the Capital, Deciphering the Mechanism of Protein Targeting Machinery in Chloroplasts
54. CUR TURCC institute conference, Capital University, Columbus, OH (2018)
55. Kameron Shrum, Tyler Jones and F.C. Liang (2018) Poster Presentation, Undergraduate Research and Creative activity Forum at Midwestern State University, Deciphering the Mechanism of Protein Targeting Machinery in Chloroplasts
56. Fu-Cheng George Liang (2018) Oral Presentation, UGROW workshop at Midwestern State University, Using Biochemical and Biophysical Approach to Study the Dynamics of Membrane Protein Chaperone
57. F.C. Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou (2017) Oral Presentation, 22^nd Biophysics Conference in I-Shou University, Kaohsiung, Taiwan, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release
58. F.C. Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou (2016) Oral Presentation, Institute of biological chemistry, Academia Sinica, Taiwan, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release
59. F.C. Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou (2016) Oral and Poster Presentation, Gordon Research Conference -Protein transport Across Cell Membranes in Galveston, TX, USA, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release
60. F.C. Liang, Camille McAvoy, Samantha Piszkiewicz, Gerard J. Kroon, Maria Yamout, Peter Wright and Shu-ou (2015) Poster Presentation, Biophysical Society 59^th Annual Meeting in Baltimore, MD., Inter-domain Dynamics of a Novel Chaperone Enables Effective Capture of Membrane Protein Substrates
61. F.C. Liang, U. Bageshwar, S. M. Musser (2012) Poster Presentation, Gordon Research Conferences -Protein transport Across Cell Membranes in Galveston, TX, USA, Position-dependent Effects of Polylysine on Sec Protein Transport.
62. F.C. Liang, U. Bageshwar, S. M. Musser (2010) Poster Presentation, Gordon Research Conferences -Protein transport Across Cell Membranes in Galveston, TX, USA, Bacterial Sec Protein Transport is Rated-limiting by Precursor Length: A Single Turnover Study.
63. F.C. Liang, U. Bageshwar, and S. M. Musser (2009) Poster Presentation, Biophysical Society 53^th Annual Meeting in Boston, MA., Bacterial Sec Protein Transport is Rated-limiting by Precursor Length: A Single Turnover Study.
64. F.C. Liang, U. Bageshwar, and S. M. Musser (2008) Oral Presentation, 13^th Annual Student Research Symposium in College of Medicine Texas A&M Health Science Center, College Station, TX., Single-turnover Transport Kinetics for the Sec Translocon Demonstrates a Single Rate-limiting Step that is Dependent on Precursor Length.
65. F.C. Liang, U. Bageshwar, W. Yang and S. M. Musser (2007) Poster Presentation, 12^th Annual Student Research Symposium in College of Medicine Texas A&M Health Science Center, College Station, TX., Single-turnover Transport Kinetics for the Sec Translocon Demonstrates a Single Rate-limiting Step that is Dependent on Precursor Length.
66. S. M. Musser, F.C. Liang, U. Bageshwar, W. Yang (2005) Poster Presentation, Gordon Research Conferences -Protein transport Across Cell Membranes meeting in Colby-Sawyer College, New London, NH, USA, Real-time Sec Protein Transport under Single Turnover Conditions.
67. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2003) Poster Presentation, Keystone Symposia-Frontiers of NMR in Molecular Biology meeting in Taos, New Mexico, USA, Glycosylation of an α-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.
68. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2002) Oral and Poster Presentation, The 16^th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Symposium: From gene to proteins: Frontiers in Biochemistry and Molecular Biology in Academia Sinica, Taiwan, Glycosylation of an α-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.
69. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2002) Poster Presentation, Graduate Students Thesis Poster Competition in Department of Chemistry, National Taiwan University, Glycosylation of an α-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.
70. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2002) Poster Presentation, The 8^th Symposium on Recent Advances in Biophysics in Academia Sinica, Taiwan, Glycosylation of an alpha-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.