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Dr. Fu-Cheng Liang

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Title
Associate Professor
Department
Chemistry
Location
Pierce Hall
Room
210
College
College of Science, Mathematics & Engineering, McCoy
Bio

Dr. Fu-Cheng Liang is an Associate Professor of Biochemistry in the Department of Chemistry at Midwestern State University (MSU). His research laboratory focuses on protein biochemistry, specifically on protein targeting and translocation in bacteria and chloroplast. More recently, he has been expanding the research to protein aggregation-prone disease, such as Alzheimer's and Parkinson's disease.

Dr. Fu-Cheng earned his B.S. in Chemistry from National Chung Cheng University in Taiwan and M.S. in Chemistry from National Taiwan University. He received his Ph.D. in Medical Science from Texas A&M Health Science Center, where he developed a fluorescence based protein translocation assay to decipher the mechanism of protein transport across bacterial cellular membrane. Dr. Fu-Cheng did his postdoc training in the Division of Chemistry and Chemical Engineering at California Institute of Technology, where he used NMR spectroscopy to study how membrane protein chaperones use spatiotemporal regulation to prevent its substrate from aggregation during the membrane protein biogenesis.

Institution Degree Graduation Date
Texas A&M Health Science Center PhD 2011
National Taiwan University MS 2002
National Chung Cheng University BS 2000
Employer Position Start Date End Date
Midwestern State University Associate Professor 09/01/2022
Midwestern State University Assistant Professor 09/01/2017 08/31/2022
California Institute of Technology Post-doctoral Scholar 07/01/2011 06/01/2017
Academia Sinica Research Assistant 07/01/2002 06/01/2004

RESEARCH INTERESTS

  • Protein targeting and transport across cell membrane
  • Protein folding and misfolding or amyloid formation
  • Membrane protein biogenesis
  • Therapeutic treatment of Alzheimer's and Parkinson's disease
  • Protein structural and functional studies by NMR and fluorescence spectroscopy

PUBLICATIONS

  1. Christopher Sun, Leah Slade, Prisca Mbonu, Hunter Ordner, Connor Mitchell, Matthew Mitchell and Fu-Cheng Liang, (2024) The FEBS Journal, 291, 158-176, Membrane Protein Chaperone and Sodium Chloride Modulate the Kinetics and Morphology of Amyloid Beta Aggregation. [Journal link]
  2. Alex Siegel, Camille Z. McAvoy, Vinh Lam, Fu-Cheng Liang, Gerard Kroon, Emily Miaou, Patrick Griffin, Peter E. Wright, Shu-ou Shan (2020) Journal of Molecular Biology, 432, 166708, A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone. [Journal link]
  3. Peng Wang, Fu-Cheng Liang, Daniel Wittmann, Alex Siegel, Shu-ou Shan, Bernhard Grimm (2018) Proceedings of the National Academy of Sciences of the United States of America, 115(15), E3588-E3596, Chloroplast SRP43 Acts as a Chaperone for Glutamyl-tRNA Reductase, the Rate-limiting Enzyme in Tetrapyrrole Biosynthesis. [Journal link]
  4. Fu-Cheng Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou Shan (2016) Proceedings of the National Academy of Sciences of the United States of America, 113(12), E1615-E1624, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release. [Journal link]
  5. Peera Jaru-Ampornpan, Fu-Cheng Liang, Alex Nisthal, Thang X. Nguyen, Steven Mayo, and Shu-ou Shan (2013) The Journal of Biological Chemistry, 288, 13431-13445, Mechanism of an ATP-independent Protein Disaggregase: II. Distinct Molecular Interactions Drive Multiple Steps during Aggregate Disassembly. [Journal link]
  6. Fu-Cheng Liang, Umesh K. Bageshwar and Siegfried M. Musser (2012) The Journal of Biological Chemistry, 287, 12703-12714, Position-dependent Effects of Polylysine on Sec Protein Transport. [Journal link]
  7. Fu-Cheng Liang, Umesh K. Bageshwar and Siegfried M. Musser (2009) Molecular Biology of the Cell, 20, 4256-4266, Bacterial Sec Protein Transport is Rate-Limited by Precursor Length: A Single Turnover Study. [Journal link]
  8. Umesh K. Bageshwar, Neal Whitaker, Fu-Cheng Liang and Siegfried M. Musser (2009) Molecular Microbiology, 74(1), 209-226, Interconvertibility of Lipid- and Translocon- Bound Forms of the Bacterial Tat Precursor pre-Sufl. [Journal link]
  9. Marianne M. Lee, Clara E. Isaza, James D. White, Rita P.-Y. Chen, George F.-C. Liang, Hannah T.-F. He, Sunney I. Chan, Michael K. Chan (2009) Proteins: Structure, Function, and Bioinformatics, 77(3), 647-657, Insight into the Substrate Length Restriction of M32 Carboxypeptidases: Characterization of Two Distinct Subfamilies. [Journal link]
  10. Rita P.-Y. Chen, Fu-Cheng Liang, Chung-Tien Lee, Rosa Zerella and Sunney I. Chan (2008) Journal of the Chinese Chemical Society 55(4), 772-781, Contributions of a Surface Hydrophobic Cluster to the Folding and Structural Stability of Ubiquitin. [Journal link]
  11. Clara E. Isaza, Xuejun Zhong, Lucia E. Rosas, James D. White, Rita P.-Y. Chen, George F.-C. Liang, Sunney I. Chan, Abhay R. Satoskar and Michael K. Chan (2008) Biochem Biophys Res Commun. 373(1), 25-29, A Proposed role for Leishmania major Carboxypeptidase in Peptide Catabolism. [Journal link]
  12. Fu-Cheng Liang, Rita P.-Y. Chen, Chun-Cheng Lin, Kuo-Ting Huang and Sunney I. Chan (2006) Biochem Biophys Res Commun. 342(2), 482-488, Tuning the Conformation Properties of a Peptide by Glycosylation and Phosphorylation. [Journal link]

PRESENTATIONS and CONFERENCES

  1. Kara Rodgers and Fu-Cheng Liang (2023) Poster presentation, American Chemical Society (ACS) Southwest Regional Meeting (SWRM), Membrane Protein Chaperone Modulates the Kinetics and Morphology of Tau Aggregation: A Potential Treatment for Alzheimer's disease.
  2. Andrew Vann and Fu-Cheng Liang (2023) Poster presentation, American Chemical Society (ACS) Southwest Regional Meeting (SWRM), Leveraging membrane protein chaperones to mitigate familial mutant amyloid beta aggregation: Prospective therapeutic approach for early-onset Alzheimer's disease.
  3. Isabella Makelaar and Fu-Cheng Liang (2023) Poster presentation, American Chemical Society (ACS) Southwest Regional Meeting (SWRM), Utilizing membrane protein chaperone to prevent and disrupt alpha synuclein protein aggregation in Parkinson's disease.
  4. George Liang (2023) Oral Presentation, UGROW workshop at Midwestern State University, Principle and Hands-on Operations of Fluorescence Spectroscopy
  5. Abigail Matthew and Fu-Cheng Liang (2023) Oral Presentation, 18th Annual UGROW Symposium at Midwestern State University, Membrane Protein Chaperone Prevents and Disrupts Alpha-Synuclein Protein Aggregation: A Potential Treatment For Parkinson's disease
  6. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, and Fu-Cheng Liang (2023) Poster Presentation, 67th Biophysical Society Annual Meeting in San Diego, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
  7. Kara Rodgers and Fu-Cheng Liang (2023) Poster presentation, MSU 20th Undergraduate Research & Creative Activity forum, Membrane Protein Chaperone Modulates the Kinetics and Morphology of Tau Aggregation: A Potential Treatment for Alzheimer's disease
  8. Abigail Guinan and Fu-Cheng Liang (2023) Poster presentation, MSU 20th Undergraduate Research & Creative Activity forum, Using Membrane Protein Chaperone to Prevent Familial Mutant of Alpha-Synuclein Protein Aggregation in Parkinson Disease
  9. Abigail Matthew and Fu-Cheng Liang (2023) Poster presentation, MSU 20th Undergraduate Research & Creative Activity forum, Using Membrane Protein Chaperone to Prevent Familial Mutant of Alpha-Synuclein Protein Aggregation in Parkinson's Disease
  10. Abigail Matthew, Abigail Guinan and Fu-Cheng Liang (2022) Poster presentation, MSU 19th Undergraduate Research & Creative Activity forum, Using Membrane Protein Chaperone to Prevent Familial Mutant of Alpha-Synuclein Protein Aggregation in Parkinson Disease
  11. Connor Mitchell, and Fu-Cheng Liang (2022) Poster Presentation, MSU 19th Undergraduate Research & Creative Activity forum, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
  12. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, and Fu-Cheng Liang (2022) Poster Presentation, MSU celebration of scholarship, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
  13. Viviana James, Leslie Cook, Isabella Makelaar, and Fu-Cheng Liang (2022) Poster presentation, MSU celebration of scholarship, Biophysical and Biochemical Characterization of a Familial Mutant of Alpha-Synuclein Protein in Parkinson Disease
  14. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, George Liang (2022), Poster Presentation, 15th Annual Honors Program Symposium, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
  15. Hunter Ordner, Chris Sun, Connor Mitchell, Matthew Mitchell, and Fu-Cheng Liang (2022) Poster Presentation, Great Plains Honors Conference, Membrane Protein Chaperone Affects the Kinetics and Morphology of Amyloid Beta Aggregation
  16. Christopher Sun and Fu-Cheng Liang (2021) Poster Presentation, Midwest Regional Undergraduate Research, Scholarly and Creative Activity Conference, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
  17. Christopher Sun and Fu-Cheng Liang (2021) Poster Presentation, National Conference on Undergraduate Research at home, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
  18. Christopher Sun and Fu-Cheng Liang (2021) Poster Presentation, Virtual UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
  19. Leah Slade and Fu-Cheng Liang (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Concentration of Sodium Chloride Determines the Aggregation Kinetics and Morphology of Amyloid Beta
  20. Christopher Sun and Fu-Cheng Liang (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Amyloid Beta Aggregation
  21. Dianna Daniel, Blanca Turner, and George Liang (2020) Oral Presentation, UGROW Symposium at Midwestern State University, Utilizing Membrane Protein Chaperone to Prevent Amyloid Plaques and Neurofibrillary Tangle Formation in Alzheimer's Disease
  22. George Liang (2020) Oral Presentation, UGROW workshop at Midwestern State University, Principles of Fluorescence Spectroscopy and Protein Purification
  23. Shermali Ratnasinghe and George Liang (2020) Poster Presentation, Abilene Christian University virtual undergraduate research festival, Identification of Membrane Protein Chaperone as Therapeutics to Prevent Protein Aggregation of Alzheimer's disease
  24. Dianna Daniel, Ryan Smith and George Liang (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Utilize Membrane Protein Chaperone as a Treatment to Ameliorate Tau Protein Aggregation
  25. Dirgha Vora, Porscha Weaver, George Liang and Jon Scales (2020) Poster Presentation, Virtual UGRCAF at Midwestern State University, Using Membrane Protein Chaperone to Rescue the Phenotype in a Fly model of Parkinson's disease
  26. Prisca Mbonu, Christopher Sun and Fu-Cheng Liang (2020) Oral Presentation, National Conference on Undergraduate Research in Bozeman, Montana (cancelled due to COVID19), Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
  27. Matthew Mitchell and Fu-Cheng Liang (2020) Poster Presentation, American Chemical Society National meeting in Philadelphia, PA (cancelled due to COVID19), Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
  28. Kameron Shrum and Fu-Cheng Liang (2020) Poster Presentation, American Chemical Society National meeting in Philadelphia (cancelled due to COVID19), LTD Does Not Function as Membrane Protein Chaperone During Protein Targeting in Chloroplast
  29. George Fu-Cheng Liang, (2020) Invited Oral Presentation, Biophysics and Quantitative Biology conference and workshop at Midwestern State University entitle, Apply membrane protein chaperone as therapeutics to prevent Alzheimer's disease
  30. Shermali Ratnasinghe and George Liang (2019) Poster Presentation, UGRCAF at Midwestern State University, Utilize Membrane Protein Chaperone to Suppress the Amyloid Beta Aggregation
  31. Dianna Daniel and George Liang (2019) Poster Presentation, UGRCAF at Midwestern State University, Utilize Membrane Protein Chaperone as a Treatment to Ameliorate Tau Protein Aggregation
  32. Fu-Cheng George Liang (2019) Oral Presentation, EURECA workshop at Midwestern State University, Directed Evolution to Improve Protein Folding in vivo
  33. Prisca Mbonu and George Liang (2019) Oral Presentation, UGRCAF at Midwestern State University, Directed Evolution of Membrane Protein Chaperone to Ameliorate Protein Aggregation-associated Disease
  34. Dolly Mombeyarara, Cheslin Maloney and George Liang (2019) Oral Presentation, UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Parkinson's Disease
  35. Prisca Mbonu, Christopher Sun and Fu-Cheng Liang (2019) Oral Presentation, UGRCAF at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
  36. Dolly Mombeyarara, Cheslin Maloney and George Liang (2019) Oral Presentation, UGROW Symposium at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Parkinson's Disease
  37. Prisca Mbonu, Christopher Sun and Fu-Cheng Liang (2019) Oral Presentation, UGROW Symposium at Midwestern State University, Applying Membrane Protein Chaperone as Therapeutics to Prevent Alzheimer's Disease
  38. Fu-Cheng George Liang (2019) Oral Presentation, UGROW workshop at Midwestern State University, Principle and Hands-on Operations of Fluorescence Spectroscopy
  39. Kameron Shrum, Tyler Jones and F.C. Liang (2019) Poster Presentation, Texas Undergraduate Research Day at the Capital, Deciphering the Mechanism of Protein Targeting Machinery in Chloroplasts
  40. CUR TURCC institute conference, Capital University, Columbus, OH (2018)
  41. Kameron Shrum, Tyler Jones and F.C. Liang (2018) Poster Presentation, Undergraduate Research and Creative activity Forum at Midwestern State University, Deciphering the Mechanism of Protein Targeting Machinery in Chloroplasts
  42. Fu-Cheng George Liang (2018) Oral Presentation, UGROW workshop at Midwestern State University, Using Biochemical and Biophysical Approach to Study the Dynamics of Membrane Protein Chaperone
  43. F.C. Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou (2017) Oral Presentation, 22nd Biophysics Conference in I-Shou University, Kaohsiung, Taiwan, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release
  44. F.C. Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou (2016) Oral Presentation, Institute of biological chemistry, Academia Sinica, Taiwan, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release
  45. F.C. Liang, Gerard J. Kroon, Camille McAvoy, Chris Chi, Peter Wright and Shu-ou (2016) Oral and Poster Presentation, Gordon Research Conference -Protein transport Across Cell Membranes in Galveston, TX, USA, Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-regulated Substrate Capture and Release
  46. F.C. Liang, Camille McAvoy, Samantha Piszkiewicz, Gerard J. Kroon, Maria Yamout, Peter Wright and Shu-ou (2015) Poster Presentation, Biophysical Society 59th Annual Meeting in Baltimore, MD., Inter-domain Dynamics of a Novel Chaperone Enables Effective Capture of Membrane Protein Substrates
  47. F.C. Liang, U. Bageshwar, S. M. Musser (2012) Poster Presentation, Gordon Research Conferences -Protein transport Across Cell Membranes in Galveston, TX, USA, Position-dependent Effects of Polylysine on Sec Protein Transport.
  48. F.C. Liang, U. Bageshwar, S. M. Musser (2010) Poster Presentation, Gordon Research Conferences -Protein transport Across Cell Membranes in Galveston, TX, USA, Bacterial Sec Protein Transport is Rated-limiting by Precursor Length: A Single Turnover Study.
  49. F.C. Liang, U. Bageshwar, and S. M. Musser (2009) Poster Presentation, Biophysical Society 53th Annual Meeting in Boston, MA., Bacterial Sec Protein Transport is Rated-limiting by Precursor Length: A Single Turnover Study.
  50. F.C. Liang, U. Bageshwar, and S. M. Musser (2008) Oral Presentation, 13th Annual Student Research Symposium in College of Medicine Texas A&M Health Science Center, College Station, TX., Single-turnover Transport Kinetics for the Sec Translocon Demonstrates a Single Rate-limiting Step that is Dependent on Precursor Length.
  51. F.C. Liang, U. Bageshwar, W. Yang and S. M. Musser (2007) Poster Presentation, 12th Annual Student Research Symposium in College of Medicine Texas A&M Health Science Center, College Station, TX., Single-turnover Transport Kinetics for the Sec Translocon Demonstrates a Single Rate-limiting Step that is Dependent on Precursor Length.
  52. S. M. Musser, F.C. Liang, U. Bageshwar, W. Yang (2005) Poster Presentation, Gordon Research Conferences -Protein transport Across Cell Membranes meeting in Colby-Sawyer College, New London, NH, USA, Real-time Sec Protein Transport under Single Turnover Conditions.
  53. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2003) Poster Presentation, Keystone Symposia-Frontiers of NMR in Molecular Biology meeting in Taos, New Mexico, USA, Glycosylation of an α-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.
  54. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2002) Oral and Poster Presentation, The 16th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Symposium: From gene to proteins: Frontiers in Biochemistry and Molecular Biology in Academia Sinica, Taiwan, Glycosylation of an α-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.
  55. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2002) Poster Presentation, Graduate Students Thesis Poster Competition in Department of Chemistry, National Taiwan University, Glycosylation of an α-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.
  56. Fu-Cheng Liang, Pei-Yeh Chen, Der-Lii Tzou, Ying-Ying Chen, Shu-Hua Chien, Chun-Cheng Lin, Yin-Ting Chang and Sunney I. Chan (2002) Poster Presentation, The 8th Symposium on Recent Advances in Biophysics in Academia Sinica, Taiwan, Glycosylation of an alpha-Helical Hairpin Peptide: A Model System for Studying the Possible Role of Glycosylation in Signal Transduction.